NANOBIOTECHNOLOGY

AIM

This course is designed to develop critical thinking, logic and planning skills in the context of Biotechnology and 21st century practices. Within the scope, the place of biotechnology and its applications will be examined, especially in the fields of genetic engineering, medicine, agriculture, industry, bioenergy and biomedical engineering. The aim of the course content is to instill in students broader assessment, analysis and application skills in conducting biotechnology research in the field of biomedical engineering; as well as to provide graduate students with the ability to use applied methods in biotechnology in their current or future studies.

CONTENT

This course contains; Biotechnology: Definition, Concept, Present and Future Place,Genes and Gene Manipulation: Recombinant DNA Technology,Cell Culture: 2D and 3D Methods,Use of Microfluidics in 3-Dimensional Cell Culture Applications: Lab-On-A-Chip and Body-On-A-Chip Technologies,Tissue Engineering Applications,Nanobiotechnology: Introduction,The Use of Nanotechnology in Therapeutic Field: Drug Delivery Systems / Nanomedicine,Characterization and Imaging Techniques: TEM, SEM, AFM,Molecule-Molecule Interactions: SPR and QCM Techniques,Cell Membrane Proteins: Phage Display Technique,Gene Therapy and Gene Silencing: Alternative Techniques,Industrial Biotechnology Overview: Fermentation / Bioprocess Techniques,Student Presentations and Analysis of Research Examples in the Literature,Student Presentations and Analysis of Research Examples in the Literature.

1. 1

   Recognize the terms bionanotechnology and nanobiotechnology

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam

2. 2

   Recognizes recombinant DNA technologies

   Taught by: Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam

3. 3

   Recognizes 2D and 3D Cell Culture methods

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam

4. 4

   Illustrates the use of nanomedicines

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

5. 5

   Evaluates the use of nanomaterials in diagnosis and treatment

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

6. 6

   Recognize tissue engineering applications

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam

WEEKLY PLAN

1. WEEK 1

   Biotechnology: Definition, Concept, Present and Future Place

   Preparation: Going through course materials

2. WEEK 2

   Genes and Gene Manipulation: Recombinant DNA Technology

   Preparation: Going through course materials

3. WEEK 3

   Cell Culture: 2D and 3D Methods

   Preparation: Going through course materials

4. WEEK 4

   Use of Microfluidics in 3-Dimensional Cell Culture Applications: Lab-On-A-Chip and Body-On-A-Chip Technologies

   Preparation: Going through course materials

5. WEEK 5

   Tissue Engineering Applications

   Preparation: Going through course materials

6. WEEK 6

   Nanobiotechnology: Introduction

   Preparation: Going through course materials

7. WEEK 7

   The Use of Nanotechnology in Therapeutic Field: Drug Delivery Systems / Nanomedicine

   Preparation: Going through course materials

8. WEEK 8

   Characterization and Imaging Techniques: TEM, SEM, AFM

   Preparation: Going through course materials

9. WEEK 9

   Molecule-Molecule Interactions: SPR and QCM Techniques

   Preparation: Going through course materials

10. WEEK 10

    Cell Membrane Proteins: Phage Display Technique

    Preparation: Going through course materials

11. WEEK 11

    Gene Therapy and Gene Silencing: Alternative Techniques

    Preparation: Going through course materials

12. WEEK 12

    Industrial Biotechnology Overview: Fermentation / Bioprocess Techniques

    Preparation: Going through course materials

13. WEEK 13

    Student Presentations and Analysis of Research Examples in the Literature

    Preparation: Going through course materials

14. WEEK 14

    Student Presentations and Analysis of Research Examples in the Literature

    Preparation: Going through course materials

ASSESSMENT

• Rate of Midterm Exam to Success30%
• Rate of Final Exam to Success70%

READING

• Godbey W.T., An Introduction to Biotechnlogy: The Science, Technology and Medical Applciations, Woodhead Publishing Series in Biomedicine, Academic Press, Elsevier 2014 Gary Walsh, Pharmaceutical Biotechnology: Concepts and Applications, John Willey and Sons, 2007 Oliver Kayser, Heribert Warzecha. Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications, Wiley-VCH, 2012 Ghasem Najafpour. Biochemical Engineering and Biotechnology, Elsevier, 2015 Lee Yuan Kun, Microbial Biotechnology: Principles and Applications, World Scientific, 2006

TEACHING STAFF

• Assist.Prof. Mehmet Hikmet ÜÇIŞIKCOORDINATOR
• Assist.Prof. Mehmet Hikmet ÜÇIŞIK